In this review, we discuss the major milestones in OCT hardware development to reach those beyond the eye clinic. In addition, advancing the portability of this technology to address opportunities in point-of-care diagnostics, telemedicine and remote monitoring may aid development of personalised medicine. Beyond high-income countries, there are 6.5 billion people with similar eye-care needs, which cannot be met by the current generation of bulky, expensive and complex OCT systems. However, more needs to be done to radically improve the access to OCT by addressing its limitations and enable penetration outside of typical clinical settings and into underserved populations. Remarkable progress has been made in the development of OCT technology to improve the speed of acquisition, the quality of images and into functional extensions of OCT such as OCT angiography. OCT systems have become ubiquitous in eye clinics but access beyond this is limited by their cost, size and the skill required to operate the devices. The FDML laser is ideal for swept-source OCT imaging, thus enabling high imaging speeds and large imaging depths.Optical coherence tomography (OCT) is a paragon of success in the translation of biophotonics science to clinical practice. This corresponds to 906 frames/second with 256 transverse pixel images, and 3.5 volumes/second with a 256×128×256 voxel element 3-D OCT data set. We demonstrate swept-source OCT imaging with acquisition rates of up to 232,000 axial scans per second. Using the FDML laser for swept-source OCT, sensitivities of 108 dB are achieved and dynamic linewidths are narrow enough to enable imaging over a 7 mm depth with only a 7.5 dB decrease in sensitivity. The average output power is 3 mW directly from the laser and 20 mW after post-amplification. Effective sweep rates of up to 290 kHz are demonstrated with a 105 nm tuning range at 1300 nm center wavelength. An FDML laser is constructed using a long fiber ring cavity, a semiconductor optical amplifier, and a tunable fiber Fabry-Perot filter. High-speed, narrowband optical frequency sweeps are generated with a repetition period equal to the fundamental or a harmonic of cavity round-trip time. FDML is analogous to active laser mode locking for short pulse generation, except that the spectrum rather than the amplitude of the light field is modulated. We demonstrate a new technique for frequency-swept laser operation-Fourier domain mode locking (FDML)-and its application for swept-source optical coherence tomography (OCT) imaging. Note: Author names will be searched in the keywords field, also, but that may find papers where the person is mentioned, rather than papers they authored.Use a comma to separate multiple people: J Smith, RL Jones, Macarthur.Use these formats for best results: Smith or J Smith.For best results, use the separate Authors field to search for author names.Use quotation marks " " around specific phrases where you want the entire phrase only.Question mark (?) - Example: "gr?y" retrieves documents containing "grey" or "gray".Asterisk ( * ) - Example: "elect*" retrieves documents containing "electron," "electronic," and "electricity".Improve efficiency in your search by using wildcards.Example: (photons AND downconversion) - pump.Example: (diode OR solid-state) AND laser.Note the Boolean sign must be in upper-case. Separate search groups with parentheses and Booleans.Keep it simple - don't use too many different parameters.
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